The Evaluation of Five Websites About Cloning Based on...

The Evaluation of five Websites about Cloning based on their Credibility and support by peer-reviewed Articles Introduction Ever since the birth of the first cloned sheep, named Dolly, the dream of human cloning has existed (Van Dijck, 1999). Cloning a mammal is described as the manipulation of an animal or human cell in order to create an identical copy of that animal’s or human’s nucleic DNA (Andrews, 1997). Though the dream of a human clone also comes with a lot of controversy regarding ethics and morals. Embryotic stem cell research, which could lead to a renewable source of human tissue, cells and eventually entire organs (Bowring, 2004), is highly controversial due to the necessity of placing a cloned embryo into a woman’s body†¦show more content†¦The website also elaborates on the history of animal cloning as it lists all animals that have successfully been cloned before, which includes: tadpole, sheep, goats, cows, mice, pigs, cats, rabbits, and a gaur. Furthermore it discusses the implication of cloned organs as transplants and touches up on the risk o f cloning. The ethical side of cloning is also discussed shortly. Even though the website is not a peer-reviewed journal or article and does not provide proper references, it provides accurate, though old, information about cloning. The information specified can be backed up by a peer-reviewed article (Bowring, 2004), but as references are missing this website does not qualify as a highly suitable website. Furthermore the information given is moderately old, as for example; the list of cloned animals misses to mention the cloning of a dog, which was successfully achieved in 2005 (Levine, 2009). Proper referencing and peer reviewing could have helped to make this website more credible but with those factors missing the â€Å"Cloning Fact Sheet† website only qualifies as a moderately proper website and is therefore ranked as number 3. 4. â€Å"Health Canada - Human Cloning† The article †Human Cloning† on the â€Å"Health-Canada† website explains the issues surrounding therapeutic and reproductive human cloning. Additionally it introduces someShow MoreRelatedCloud Computing Security67046 Words   |  269 Pagescloudsecurityalliance.org/guidance/csaguide.v2.1.pdf (version 2 guidance) http://www.cloudsecurityalliance.org/guidance/csaguide.v1.0.pdf (version 1 guidance) In a departure from the second version of our guidance, each domain was assigned its own editor and peer reviewed by industry experts. The structure and numbering of the domains align with industry standards and best practices. We encourage the adoption of this guidance as a good operating practice in strategic management of cloud services. These white papersRead MoreMarketing Management 14th Edition Test Bank Kotler Test Bank173911 Words   |  696 PagesMarketing Management, 14e (Kotler/Keller) Chapter 1 Defining Marketing for the 21st Century 1) Which of the following statements about marketing is true? A) It is of little importance when products are standardized. B) It can help create jobs in the economy by increasing demand for goods and services. C) It helps to build a loyal customer base but has no impact on a firms intangible assets. D) It is more important for bigger organizations than smaller ones. E) It is seldom used by nonprofitRead MoreOrganisational Theory230255 Words   |  922 Pagestruth is out there, and we can objectively know it Philosophical disputes around the role of the subjective in science Epistemological and ontolological disputes: how can we ever know the ‘truth’ and is there an ‘out there’? A few words of warning about the term postmodernism Overview of the structure and rationale of the book Chapter summaries Chapter 2: Modernist organization theory: back to the future? Chapter 3: Neo-modernist organization theory: putting people first? Chapter 4: Neo-modernist

Greek Religion Ancient Greeks - 1704 Words

Ancient Greeks worshipped lots of different gods. They believed many gods appeared in human form and were provided with superhuman strength. The Greeks usually worshipped in sanctuaries located within the city or the country. A sanctuary was a well-defined sacred space set apart usually by an enclosure wall. They also worshipped in temples. Temples benefited from their natural surroundings, helping the expression of character divinities. The Greeks also had a Christian Orthodox church they used. The Greek religion had a total of twelve gods, each representing a certain aspect of human behavior. Religion was always present. The Greeks had rituals, myths, and temples with the beliefs being widespread so the Greek government could function. Each god did a different thing, with different powers. Each were always needed, and their powers were always necessary. They usually all got along unless one was made mad. Greek religion was combinations of old Minoan beliefs. To some extent always remained familiar but its far from easy understanding. The Greeks thought of their religion as unique and unrepeatable. They believed that after death, a soul went on a journey to a place called the underworld (â€Å"Everyday life, Beliefs, and Myths†). If the soul went to the underworld the god of death would cut off a lock of your hair as you died. Hermes, the messenger god, would then lead you to the river, Styx. If your body was once buried the ferryman god would deliver you across the river.Show MoreRelatedGreek Religion : Ancient Greece1601 Words   |  7 PagesAlthough Greek religion is no longer popular because of it s diversity compared to religion today, it had a great standing back in Ancient Greece; Many aspects played a role in creating it s foundation such as the deities, worship and rituals, and mystics and oracles. Greek religion was considered polytheistic for it s belief in many gods and they were called upon during everyday trials and tribulations, providing their wisdom and guidance. The deities depicted in Greek mythology had strangeRead MoreAncient Greek Religion Essay1869 Words   |  8 PagesAncient Greek Religion: Mycenaean to Classical Period Ancient Greece has been a religion- centered culture since the earliest period of habitation in Greece, the Pre-Mycenaean/Mycenaean period. Also through to the Dark Ages to the Classical period. It is a religiously centered civilization, and did have significant changes in the how it was incorporated into people’s daily lives. Religion is important to know about the Ancient Greeks because through it we are able to understand how they lived theirRead MoreAncient Greek And Roman Religion Essay1060 Words   |  5 PagesThe ancient Greek and Roman religion was the belief in God. They had similar views, but also some differences. It composed of many meaningful Gods and Goddesses that played the part in the everyday life of the average Roman and the Greek citizen. Before going into their beliefs and many strange legends, we must consider what kind of beings these divinities were. From history, there’s the first dynasty that consisted of the origin of the world, Uranus and Ge. The ancient Greeks had several theoriesRead MoreAncient Greek Religion And Ancient Greece1955 Words   |  8 PagesThough Ancient Greece was made up of many different regions and colonies, these 3 things were almost always in view. The ancient Greeks worshiped many different gods and goddesses that each controlled something in the mortal world. What was different about their gods and goddesses was that they were very human like. They looked like mortals, had thoughts like mortals, and they even quarreled with each other like we do. Ancient Greek religion is also known as Greek Mythology, Classical Religion, andRead MoreEssay on Ancient Greek and Mesopotamian Religions - a Comparison1501 Words   |  7 PagesAncient Religions By: MLB As civilization has progressed through the ages, many religions have arisen and taken hold around the world, two if the most interesting, being the religious beliefs of the ancient Mesopotamian and the Greeks. These two religions were practiced in different areas and at different times and, therefore, show that religion has played a critical role in every society and civilization. No matter how it is organized or what typeRead MoreHow Did The Religion Of Ancient Greeks Played A Role?1201 Words   |  5 PagesKenzay Rivers Ms. Finney How did the religion of ancient Greeks played a role in their daily lives? 10 November 2016 How did the religion of ancient Greeks played a role in their daily lives? In the ancient Greek world, religion was personal, direct, and present in its citizens’ daily lives. During this time, they participated in animal sacrifices and offerings, created myths to explain the beginning of the human race and gave reverence to their gods by building temples which controlled theRead More Classical Greek Architecture Essay1279 Words   |  6 PagesClassical Greek Architecture The reuse of older art works in contemporary times is not an uncommon occurrence, and many examples can be seen throughout the day as one goes from place to place. Even when one is browsing through the World Wide Web can many uses of older art and architecture be seen, as with the example shown. 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During this time, Greece was near the middle of its Archaic period, a period of technological, social, political, and cultural innovations. This was the period in which the first true alphabet system arose, the system which allowed Hesiod and other poets like him to record permanently the oral stories and lyrics so important to Greek culture. This was also the time in which the Greek polis emergedRead MoreAnalysis Of Neil Fraser s The Golden Age 1893 Words   |  8 PagesTheatre History Explained Neil Fraser outlines the history of theatre from Greek and Roman times, all the way through the twentieth century. Fraser makes a claim that theatre truly began in Greek culture with even the Roma’s looking upon that time as â€Å"the golden age†. â€Å"The Romans looked back on Greek theatre of circa 600BC as a golden age, and we can still make a case for the great plays of that period as having never been bettered.† (Fraser, 2004, pg.5). Some of the more important highlights of

Conservative vs. Liberal Free Essays

Conservative vs. Liberal Dimitri Khago PSY/201 Sunday, August 05, 2012 Mariah Degruy Conservatives vs. Liberals Not just as Americans but as human beings we all want the same basic things in our daily lives. We will write a custom essay sample on Conservative vs. Liberal or any similar topic only for you Order Now We all seek freedom and yearn for prosperity. We all seek for what is fair in life and not just our lives separately, but the lives of our nation’s people. We want less people to suffer as much as possible, especially our children. We all seek the best for our health being. We all want a crime free nation and crime free streets in our communities. We all want a freedom to speak and voice our opinions; yet the one major key argument is how do we achieve all of these? With all that has been going on in our nation’s economy, we begin to analyze one of the very most important, yet controversial political issue that we are facing: Liberal or Conservative? Although we are united as a whole nation, but when concerning our nation’s political policies we are very much divided. Each of us has our own beliefs and our own opinion, but the beauty of this is that this is what makes this country. This belief was instilled in our bloods from the day this great nation was formed, by our political forefathers up until now. We sometimes call these beliefs Left or Right based on the political spectrum. The political spectrum We have learned to become conservative toward the nation, our nation’s people and our nation’s policies, as well as we have learned to become liberal toward the nation, our people and our nation’s policies. Which is right you might ask, that all depends on every individuals different view and opinion to do what is right and best for them? Conservatives and Liberals differ on what they believe is correct for the government. They seek different essential needs, different government program support, different social views, and very different economic views. As humans we all seek the same basic needs to live. These needs are Life, Liberty, and Pursuit of happiness a well-known phrase from the United States Declaration of Independence. We all have the right to lead our own life in which we so choose. We all have the right to have our belief and make our own decisions and stand to our own judgments. The most important matter is that we have the right to do whatever it takes to make ourselves feel happy without harming anyone one stepping over the boundaries of others. In order to protect our individual human rights the bill of rights were established. These laws which allow the people the ability to live by these deserved rights as a human being are what distinguish us from a free person and one who is not free. If one is convicted of a felony these particular laws spoken of are no longer valid to them – the right to vote, the right to serve on a jury, and the right to bear arms are all void. Although some states are adjusting these laws to their own liking, you as a criminal are no longer privileged to take part in these opportunities because of the crime committed, they are therefore taken away from you â€Å"†¦Other states may permanently ban felons from voting even after being released from prison, parole, and probation, and having paid all their fines. †(State Felon Voting Laws). There are many programs in which our government runs, and many of these programs are the split between the conservative or the liberal side. Liberals seem to view their government better as a larger government and support those programs which make this a reality. These include many programs, but one in particular is welfare. In the eyes of a liberal, this program is looked very highly upon. It helps those in need the ability to stand on their feet and not be out on the street. Although ideally this is a great help, but nowadays in our country, many people seem to take advantage of this opportunity and cheating the rest of society who need this help. With the educational program, a liberal supports not only public schools and a higher teacher salary, but also smaller classroom for the students. They support the idea that the classrooms should not be thirty-plus children, but also smaller more controlled environment† Vouchers take money away from public schools. † (Conservative vs. Liberal Beliefs. ). Now if you were to ask a conservative about education, they believe in the art of competition â€Å"School vouchers create competition and therefore encourage schools to improve performance. (Conservative vs. Liberal Beliefs. ). Schools should be all private so that they compete with lower costs and the parents have the opportunity to decide where they want their child to attend, and what kind of education they want for their child. Another program a conservative strongly believes in is canceling all the failed social support programs. Why should a country hold on to a program that is not helping anyone that is in need o f the assistance, but financially supporting those well off, and are working and supporting their own families. Although being in the twenty-first century has expanded our view upon socialistic views, conservatives feel that we should not change our ruling on marriage and that it must stay traditional between a man and a woman. Since America was founded on grounds of religious freedom, and the Bible was and is our most highly looked upon views, conservatives feel that we shall stick to these traditional views and not support the idea of abortion or embryonic stem cell research. One must not abort a child, since that is the same as murder â€Å"Abortion is the murder of a human being. † (Conservative vs. Liberal Beliefs. ). One must also not participate in stem cell research since that too is destroying a life. This is where the argument comes in on the Liberal side. Liberals believe it is not up to us to decide if marriage shall stay between a man and a woman, what is so wrong with a man and man marrying or a woman and woman? Since this country was found on the principles of freedom and the rights to make our own decisions, the personal lives of Americans shall not be dictated by the government because of what they think is right. It has not yet been proven that a fetus inside a woman is a child or a fetus. The argument remains that a child is only a child when it takes its first breath, or that a child is a child when it is conceived. Shouldn’t the mother decide if she wants to give birth to this fetus? She will be bearing all the pain, so it should be her right to decide â€Å"A woman has the right to decide what happens with her body. A fetus is not a human life, so it does not have separate individual rights. † (Conservative vs. Liberal Beliefs. ). Now if you can save a life wouldn’t you? If you aren’t hurting anyone or anything with embryonic stem cell research, then scientist should be able to harvest these stem cells to help a life â€Å"†¦Stem cells derived from embryos in the very earliest stages of development; these cells have long been thought by scientists to have an xtraordinary potential for alleviating the suffering caused by conditions ranging from diabetes to Alzheimer’s disease to spinal cord injury. † (Gold). Money is what runs the country, one thing these two political stances have in common are the want and need for more jobs. A conservative wants the federal government not to tax the rich as high and should spend so much less. These big businesses should get the tax breaks they want and deserve to increase and generate their revenue, so that they can stimulate and keep the economy stable and grow to be much stronger. Liberal’s on the other hand believe in quite opposite of the conservative behalf they believe that the rich should be taxed more than the poor since they can afford to pay a little extra money in order to have a greater government â€Å"The less government we have, the more liberty we have. † (Amy). They also approach with saying that these big businesses should be taxed more and pay a larger amount of income tax from their profits to help support and provide for Medi-Cal, Medic-Aid, and Welfare. In conclusion regardless on which of side of the political spectrum you stand with; either you are a conservative or a liberal, at the end you center all your opinions to your own political beliefs based on your own personal ethics. With all that has been going on in our nation’s economy, we begin to analyze one of the very most important, yet controversial political issue that we are facing: Liberal or Conservative? You must decide on your own what you feel the essential needs are, government program support, social support, or the economic support you feel your country shall provide you with. References Conservative vs. Liberal Beliefs. (2005). Retrieved from http://www. studentnewsdaily. com/conservative-vs-liberal-beliefs/ State Felon Voting Laws. (2012). Retrieved from http://felonvoting. procon. org/view. resource. php? resourceID=286 Amy, D. J. (2007). A Guide to Rebutting Right-Wing Criticisms of Government. Retrieved from http://www. governmentisgood. com/feature. php? fid=14 Gold, R. B. (2004). Embryonic Stem Cell Researchaâ‚ ¬Ã¢â‚¬ Old Controversy; New Debate. Retrieved from http://www. guttmacher. org/pubs/tgr/07/4/gr070404. html How to cite Conservative vs. Liberal, Essay examples

Development of Corporate Governance-Free-Samples-Myassignment

Question: Outline the development of Corporate Governance from the traditional approach through to the modern approach. Discuss the characteristics and principles of each approach. Answer: Introduction Corporate governance is the process by which corporate organisations are monitored and administered. Corporate governance is needed for the modern organizations to maintain a balance between the organizational goals and the interest of stakeholders of the organization. After globalisation, the work environment of corporations has changed. With the increase in opportunities, the accountability of the corporation has also increased. Large corporate and even small organisations have collapsed due to the lack of proper governance. The factors that are accountable are: the motive of social welfare and their responsibility, delegation, autonomy, authority, power and other disclosure agreements and their legitimacy. The collapse of the corporations like Enron, Lehman Brothers, Robert Maxwell due to fraudulent cases are the most important and noteworthy instances (Agrawal and Cooper 2017). These collapses have shaken the roots of the respected governance bodies. The Regulations and codes of ethics have been redefined after the government has learnt the lesson because of major losses in the economy and job cuts. The scandals have made people aware of the fraudulent ways of the company standards and procedures to be checked (Solomon, 2013). The scandals Enron is a company in Houston founded established by Kenneth Lay and Jeffrey Skilling in the year 1985. It became the largest energy providing organization in USA. Later on the company expanded to Oil and natural gases division, broadband and internet connections, Electricity, water and paper trading (Agrawal and Cooper 2017). This expansion helped the company to diversify in the global international market. After the bankruptcy, the analysis revealed that the company has significant problems regarding the dealings reported on directors. Different questions were raised regarding Enrons managerial problems and corporate ethical approaches they took when they were in active business. It showed several unethical means that was employed by the organisation over the years. In 2001, the company announced a major loss and was coaxed to admit their false account and profitability information of $600 million (Fox et al .2016). The accounting method of Enron was very unethical as they presente d non-transparent financial statements. In accrual accounting method their recorded cost and revenue were also incorrect and misleading. The hidden debt, taking excessive risks, violation in formation of balance sheets, disclosure of minimal details, overstated equity and profits to engage more shareholders were the unethical approaches adopted by the organization. These helped them to hide their losses for a short period but the strategy failed. The proliferation of the company books, checks and balances were detected to be filled with unethical practises and also a major cause of the breakdown in corporations governance (Shrives and Brennan 2015). The trials in court after the companys decline highlighted major issues that were overlooked by the civil lawyers. Excessive use of power by the CEO, private undisclosed partnerships was also the cause of the Enrons fall. The Parmalet Diarys scandal was a result of a failure in the governance and accounting discrepancies in privately owned corporate entity (McAlister et al. 2016). The Italian Food companys governance failed due to the founders unethical practises. He controlled the shareholders and channelled their resources illegally. This was also done at the expense of minority shareholders resources. The monitoring and controlling process failed leading to the Parmalats crisis. The Organizational structure was at fault as both the CEO and the owner held the position of chairperson as per the codes of Parmalat Finanziaria (McAlister et al. 2016). The lack of compliance of the companys independent policy related to the controlling of shareholders interests affected the company. The monitoring structure of the companys governance framework, made the abuse of power and fraudulent activity to rise easily in that situation. A similar case can be discussed form the UK. The infamous case of Robert Maxwell and his media corporation is a perfect example of the failure in governance framework. In order to survive in the sector he adopted fraudulent practises. It was estimated that they stole 727 million Euros from the pension funds of the two public companies as well as the assets from the companies (McAlister et al. 2016). The undivided control in operation in the Maxwell Communication and governance ultimately caused the downfall of the company. The non-executive directors were involved in the function of performing independent function. The auditors were involved in providing non-transparent information of financial activities and practises. The pension fund trustees also failed to observe the money laundering activities of the companies by transferring the money from one unidentified account to another (Eling and Marek 2014). This scandal also helped in raising the issues related to corporate governance ethics and codes. It was also reasoned that leadership of the company was very much incapable of using the stewardship of the company and making it properly function under their guidance (McAlister et al. 2016). During the recession years 2008-2009, Lehman Brothers collapsed because of the reasons aforementioned (Eling and Marek 2014). The unethical business practises of the top executives in the board and auditing firms were the reason of the collapse of the company. The discrepancies in the transaction and imbalance in the balance sheet drew attention of the company. The financial information was not disclosed then. Later on, the corporation got involved in a debt of $ 613 billion where unsecured creditors in different countries owed money from them (Eling and Marek 2014). The traditional approach The corporate governance is a considerably old concept, evolving after the private organisations were established. The firms provided value of control regarding governance and ethics. Most importantly, the problem of monitoring and directing the process is one of the most important parts of governing the organisation (Akinteye et al. 2015). The traditional approach also included the overview of the agency problem; ownership and control of the large publicly held corporation were also questionable. The legislative power of the company was directed by the economic policies set by government (Zalata and Roberts 2016). Traditional approach emphasises on the models that only takes into consideration the exchange and transactions taking place in the market among the investors, customers, suppliers, employees and other groups (Larcker and Tayan 2015.). The two tier models were responsible for the being the foundation of governance structure of companies. It also takes into account the agenc y costs and transactional cost related to the financial structure of the company. It also includes the legal responsibilities of the directors as well as the shareholders legal mechanisms used in business. The corporate laws started to reform after 2004 (Shrives and Brennan 2015). The alternative models were also adopted during this time. There are two types of theoretical framework, one is of broader view and the other is of narrower view. Thus, considering all factors, the models were defined for providing a solution for the companies that wants to enter the industry. The theoretical framework of the governance structure is one of the most important part to be considered. The traditional approach to share ownership and Anglo-American corporate governance goes by the transactional and agency theory of system (Shrives and Brennan 2015). In the modern joint stock market of America, the 910 companies were included. In the perspective of UK, corporate governance was functional and the role of board of directors and owners, chief executives were defined perfectly. The focus was on the activism of the shareholders instruments. The transparency and financial reporting were there but the Financial Reporting Council did not play its part effectively (Zalata and Roberts 2016). The companies that were involved in Financial Crisis were involved in breaking the codes of ethics and illegal activities. Implementation of the European Union Audit Regulations and Directives Section C3 reviewed the changes in information that the companies started to send regarding solvency, liquidity, viability and risk management and investment changes (Akinteye et al. 2015). The scandals related to those data provided in the companys journals were wrong which later stimulated in their downfall. The structure of the corporate governance was also at fault the company. Many companies were characterised as family owned and then different kinds of features were seen in the process. The traditional approach to corporate governance is based on the agency theory, which takes into consideration the factors of financial paradigm and economic factors. The agents that are considered in this supervisions and control structure are stakeholders of the organization (Zalata and Roberts 2016). The principles that are used in this structure are the delegation of the everyday decision making system, related to the shareholders. In this theory, shareholders wealth maximisation was an important motive of building the rules of corporate governance. The managers play with egoism and are known for being short-termism according to this traditional approach that has affected the company (Akinteye et al. 2015). The reduction in shareholders welfare is known as the residual loss in this theory. Transaction cost theory, takes into account the important element of the behavioural theory and its components. The resources of the market that are used to coordinate the transaction among the companies are related costs control theory of transaction. Internalisation of the transaction related activities is of utmost importance in this regard. The bounded rationality is an essential part of this theory (Shrives and Brennan 2015). According to this theory, the managers are individuals who are opportunistic by nature. The modern approach Stakeholders theory was developed considering the individual entities. Incorporation of corporate accountability is one of the most important elements in this concept. The broad research and unified approach of this theory makes it more relevant in the current time. This research takes the best out of the traditional approach of the corporate governance as well as incorporates philosophy, ethics, political theory, economical factors and stakeholders of the organisation (Dimopoulos and Wagner 2016). The commonality acknowledged in this theory is in the exchange relationship among the stakeholders. The stakeholders are shareholders, employees, suppliers, customers, creditors and all the personnel directly or indirectly related to the company. The modern approach of corporate governance is of the following factors. They are supervision, cooperation and information exchange, coordination, decision-making, consulting, supervision. These significant matters are considered in this report. The task in hand is more considered in this process, emphasis is given on the situation of economic, financial, organisational, and market. There is one theory that needs to be taken into consideration in defining the modern approach, the stewardship theory (Larcker and Tayan 2015). The function of this theory is to consider the supervisory board in relation with management. The main factor that is considered in the modern approach is the motivation factor. The agent motivation was purely financial. The behavioural approach was not considered in the old age. This gave an outcome in the governance structure, which was less effective in nature. The stewardship theory talks about the control mechanisms of the individuals in situational factors. The situational factors talks about the trust, employee engagement, collectivism, power distance and collaboration needs of the company (Boreiko and Murgia 2016). This is the main contrast from the agency theory. The governance of the companies is mainly based on the guidelines of Corporate Governance given by the OECD org amended on 2004 (Larcker and Tayan 2015). This organisation dictates the basic rules of the governance structure, accountability limitations. The following is the features, which need to be considered. The key ownership functions, rights and regulations of the companies regarding their shareholders are to be decided first. Treatments should be similar for all shareholders and not based on their ownership of shares Roles are correctly defined by this process Responsibility of the companys body (Dimopoulos and Wagner 2016) The recently added feature of social welfare that is included in the corporate structure depicts that the governance must give emphasis in planning the welfare of the society. The modern approach has different views that are presented to the government. The new recommendations presented have considered different holes that have been identified from the previous mishaps in corporate governance. The Hample report, Cadbury report and Higgs report were presented based on the modernisation of the corporate governance spirit (Boreiko and Murgia 2016). Different factors involved in this new method of calculation of directors remuneration are also given in the approach. Corporate social responsibility, social welfare improvement in pension fund regulations and other rules regarding corporate governance needs to be adopted. Shareholders reports, trustees role, responsibilities, and information that need to be presented in the report and other aspects of the company should be transparent accor ding the new approach. The impact of the new approach helps in combining the codes in UK Companys directors and institutional investors relationship. Pro activism of the shareholding governance is also considered in the matter. Critical discussion in the differences among the approaches used in UK and US corporate governance The separation in the ownership and control was incorporated as an essential policy in the new approach. The companies, which was in major need of improvement learnt from the scandals that plagued the noted companies as discussed above. This also affected the economy of those countries immensely. The scandals also involved major theft in some cases. Different reports on the failure issues were presented in the federal government of USA, they presented the Sarbanes-Oxley Act 2002 in USA after the report was submitted, Higgs report in January 2001, and Smiths Report was presented in UK around that time (Al-Najjar and Abed 2014). Lack of solid foundations in UK government officials lead the investors to believe that they can earn huge profits and this helped them earning profit after investing in technological stocks. This was a good incident that happened in the late 1990s (Akinteye et al. 2015). The unlimited liability of the investors implied that the policies were not effective regarding investments. The Limited Liability act 1855 helped the company to rip off all the shareholders to earn profits that was due for the shareholders(Al-Najjar and Abed 2014). There have been significant influences of the collapse of Giant Corporation like Enron and WorldCom, which made it necessary to redefine the possible changes in the governance structures. The Hampel Report 1998 presented in the Britain is a successor of the Cadbury report. The report is based on the regulation of directors remunerations. This also summarizes the best practises of the UK companies. The UK companies defined separate rules in their report of governance. The common rules for directors fiduciary duties, Companies act and documents 1985 and listing rules in UK are different than the US regulations, that includes the SOX act 2002 (Honor et al. 2015). The Sarbanes-Oxley Act 2002 is detailed regulation listed for the companies in US and is very different from the rules of comply and explain in UK (Al-Najjar and Abed 2014). The US regulations depend on the fines, penalties and imprisonment for violating the requirements of SOX act. The securities act 2004 consists of audit, in vestigations and community requirements of the companies in UK (Armstrong et al. 2015). The committee has greater power in this regard. However, the establishments of the PCAOB (Public Company Accounting Oversight Board) have the ultimate power regarding all the auditors and US security law (Bushee et al. 2013) in the country. The provisions stated in the states regulation in SOX, that there must be mandatory rotations in the audit partners but the restrictions in non-audit services. The external auditors can provide only the non-audit services. However, in US the auditors or the audit partners of the company can provide the audit and non-audit services (Bain and Band 2016). The CEO and CFOs of the company must regularly certify the reports to help the company mitigate the penalties of false credit citations or engaging in criminal activities (Zalata and Robert 2016). However, in UK the directors report must contain the statement of the directors regarding relevancy of the audit inf ormation or false information given in the report. It is criminal offense for the company to make a false statement. The US legislations contain the prohibition act effective on insider trading during the pension fund scandal that happened in the country. The board does not specify it but the companies must go by the pension part 5 of the criminal justice act 1993 or Market Abuse Regime (Elmagrhi et al. 2017). However, the rules of management report and internal audit attested that the management report given in US SOC and SEC and adoption of codes of ethics is essential but it does not have any equivalent rules in UK regulations. In UK, it is expected that the companies will maintain the minimum ethics as a matter of fact (Carberry et al. 2017). Issues in the approaches as well as the benefits For a company it is essential to incorporate corporate governance in the operations of the business. Both of the discussed regulations, SOX in US and Smith, Higgs, Cadbury, Greenburg report in UK and other reports has very important part in the corporate governance (Tricker and Tricker, 2015). The separation in the roles of CEO, CFO, chairman and board of directors have provided the companies with an advantage of taking different perspectives and thus form different viewpoints. The codes of corporate governance and ethics in other companies are strictly maintained after the scandals of the companies discussed above. The main issue in modern approach of corporate governance is, it does not identify consistency and significance in the relationships between performance of the firm and executives remuneration (Elmagrhi et al. 2017). The monitoring and the evaluation system is also given lesser emphasis in the acts that needs to be implemented. The Cadbury Act in UK does not consider the accounting standard changes that are modified after the commencements of the report (Denis 2016). The share repurchase from the shareholders are also an issue in corporate governance approach, which should be considered. These issues have been highlighted in this framework. Conclusion The constant update of the corporate governance ethics and codes of practice along methodical review of corporate governance structures are necessary to avoid downfall of companies like Enron in the future. The concept of corporate governance deals with the changes in the approach of the top level management along with the effective implementation of human resource in the company. The approach to use the penalties, fines and restrictions in case of illegal activities and breach of any contract is effective. The use of rational external auditing partners and the tight control in the internal audit members in both the countries, especially the US regulations are very essential and effective. This provides the company to safeguard the information as well as provide a transparent report. References Agrawal, A. and Cooper, T., 2017. Corporate governance consequences of accounting scandals: Evidence from top management, CFO and auditor turnover.Quarterly Journal of Finance,7(01), p.1650014. Aguilera, R.V., Desender, K., Bednar, M.K. and Lee, J.H., 2015. Connecting the dots: Bringing external corporate governance into the corporate governance puzzle.Academy of Management Annals,9(1), pp.483-573. Akinteye, S.A., York, D.O. and Quat-Ullah, H., 2015. Corporate Governance Mechanism: An Investigation of the Internal Audit Function Quality in Nigerian Listed Firms.International Journal of Business and Social Science,6(1). Al-Najjar, B. and Abed, S., 2014. The association between disclosure of forward-looking information and corporate governance mechanisms: Evidence from the UK before the financial crisis period.Managerial Auditing Journal,29(7), pp.578-595. Armstrong, C.S., Blouin, J.L., Jagolinzer, A.D. and Larcker, D.F., 2015. Corporate governance, incentives, and tax avoidance.Journal of Accounting and Economics,60(1), pp.1-17. Bain, N. and Band, D., 2016.Winning ways through corporate governance. Springer. Boreiko, D. and Murgia, M., 2016. Corporate Governance and Restructuring Through Spin-Offs: European Evidence. InThe Financial Crisis(pp. 7-47). Springer International Publishing. Bushee, B.J., Carter, M.E. and Gerakos, J., 2013. Institutional investor preferences for corporate governance mechanisms.Journal of Management Accounting Research,26(2), pp.123-149. Carberry, E. and Zajac, E., 2017, January. How US Corporations Changed Executive Compensation after Enron: Substance and Symbol. InAcademy of Management Proceedings(Vol. 2017, No. 1, p. 15134). Academy of Management. Denis, D., 2016. Corporate Governance and the Goal of the Firm: In Defense of Shareholder Wealth Maximization.Financial Review,51(4), pp.467-480. Dimopoulos, T. and Wagner, H.F., 2016. Corporate Governance and CEO Turnover Decisions. Eling, M. and Marek, S.D., 2014. Corporate governance and risk taking: Evidence from the UK and German insurance markets.Journal of Risk and Insurance,81(3), pp.653-682. Elmagrhi, M., Ntim, C.G., Crossely, R., Malagila, J., Fosu, S. and Vu, T., 2017. Corporate governance and dividend pay-out policy in UK listed SMEs: The effects of corporate board characteristics. Fox, M.B., Gilson, R.J. and Palia, D., 2016. Corporate Governance Changes as a Signal: Contextualizing the Performance Link. Hilscher, J., Landskroner, Y. and Raviv, A., 2014. 0BThe Raymond Ackerman Family Chair 1Bin Israeli Corporate Governance. Honor, F., Munari, F. and de La Potterie, B.V.P., 2015. Corporate governance practices and companies RD intensity: Evidence from European countries.Research policy,44(2), pp.533-543. Larcker, D. and Tayan, B., 2015.Corporate governance matters: A closer look at organizational choices and their consequences. Pearson Education. Lee, K. and Barnes, L., 2017. Corporate Governance and Performance in Hong Kong Founded Family Firms: Evidence From the Hang Seng Composite Industry Index.The Journal of Developing Areas,51(1), pp.401-410. McAlister, D.T., Marcos, S. and Ferrell, O.C., 2016. Corporate governance and ethical leadership.Business Ethics: New Challenges for Business Schools and Corporate Leaders: New Challenges for Business Schools and Corporate Leaders, p.56. McCahery, J.A., Sautner, Z. and Starks, L.T., 2016. Behind the scenes: The corporate governance preferences of institutional investors.The Journal of Finance,71(6), pp.2905-2932. Misangyi, V.F. and Acharya, A.G., 2014. Substitutes or complements? A configurational examination of corporate governance mechanisms.Academy of Management Journal,57(6), pp.1681-1705. Shrives, P.J. and Brennan, N.M., 2015. A typology for exploring the quality of explanations for non-compliance with UK corporate governance regulations.The British Accounting Review,47(1), pp.85-99. Solomon, J. (2013).Corporate Governance and Accountability. 4th ed. Wiley. Solomon, J.F., Solomon, A., Joseph, N.L. and Norton, S.D., 2013. Impression management, myth creation and fabrication in private social and environmental reporting: Insights from Erving Goffman.Accounting, organizations and society,38(3), pp.195-213. Tricker, R.B. and Tricker, R.I., 2015.Corporate governance: Principles, policies, and practices. Oxford University Press, USA. Zalata, A. and Roberts, C., 2016. Internal Corporate Governance and Classification Shifting Practices: An Analysis of UK Corporate Behavior.Journal of Accounting, Auditing Finance,31(1), pp.51-78.

Karyotyping in Genetic Counseling Programme Essay Example

Karyotyping in Genetic Counseling Programme Paper Genetic counselling is a counselling process that deals with disorders within the family. This process involves a counsellor who helps the family or the person in the following ways: (a) discusses medical facts and informs about the diagnosis and the cause of the disorder and the cure; (b) informs the way heredity can cause disorders and the individuals in the family that possess risk; (c) helps to understand the cure but keeps in mind awareness of the comeback of the disease; (d) chooses the cure which they find appropriate, keeping in mind the risk and the family goals and acts accordingly to the decision; and (e) tries to make the best arrangements for the necessary adjustments within the family due to the disorder and/or to the risk of the reappearance of that disorder (Fraser, 1974). 1. Genetic Counselling Origin, Nature, and Goals Genetic counselling was established in 1947 and its main purpose was to explain the relationship between clinical geneticists and others who provide relevant information about etiology, history of nature, and occurrences of hereditary disorder risks. Its main aim was to promote a viable trend towards the various goals and values of those counselled and to dispel the association with eugenics that is relative to past practices of genetic counselling. The addition of nondirective approach in genetic counselling by the Rogerian psychology, has set it as standard in 1974. This standard remained consistent over time with the objective of early purveyors of genetic information with those scientists who were used to give information without providing advice (Mahowald, 1998). 2. Genetics Counselling Programme: Its Importance 2. 1 Reproductive decision-making: Some studies have defined effectiveness as having an impact on reproductive decision-making, leading to a potential reduction in affected births (Pilnick, 2001). Hildes at al. for example, reported a pilot neonatal screening programme for Duchenne muscular dystrophy (DMD), offering prenatal diagnosis for future pregnancies in women who are at risk. However, prenatal diagnosis was only actually carried out in two out of seven subsequent pregnancies. We will write a custom essay sample on Karyotyping in Genetic Counseling Programme specifically for you for only $16.38 $13.9/page Order now We will write a custom essay sample on Karyotyping in Genetic Counseling Programme specifically for you FOR ONLY $16.38 $13.9/page Hire Writer We will write a custom essay sample on Karyotyping in Genetic Counseling Programme specifically for you FOR ONLY $16.38 $13.9/page Hire Writer The authors conclude that such programmes â€Å"may not be an effective way of decreasing the number of repeat cases of DMD within families† (Hildes, 1993). Another study of clients who reported reactions to genetic counselling, found that almost half (43. 5%) of 628 clients completing questionnaires six months after their counselling session, reported that their reproductive plans had been influenced. However, the change and stability of reproductive plan patterns of both groups -self-described influenced and not influenced were similar. Such an approach is always likely to be contentious because of its thinly veiled eugenicism (Wertz, 1986). This has led to a search for other possible outcome measures. 2. 2 Information recall: Swerts for instance looked at the shadow induced by both genetics counselling and neural tube defects (NTD) and prenatal diagnosis for Down’s syndrome (DS), and also practised a simple information-delivery model, evaluating effectiveness by measuring recipients’ recall rather than their subsequent reproductive decisions (Swerts, 1992). Measurements of knowledge acquired or information recalled after counselling are frequent proxies for effectiveness, reflecting the common attempt to avoid the stigma of eugenics by presenting counselling as an educational intervention to enhance recipients’ autonomy. A number of studies have compared ‘before’ and ‘after’ knowledge of genetic factors amongst various client groups (Pilnick, 2001). 2. 3 Anxiety reduction: Anxiety has the potential to increase among genetic tested subjects. Mennie et al. found that, compared with controls who were identified as non-carriers, Cystic Fibrosis carriers and their partners showed a significant increase in generalized psychological disturbance over a four-day period, while awaiting the partners’ test results. This was attributed to anxiety and depression. After the results had been released, both parties returned to their control levels. Watson et al. also examined anxiety in those being screened to ascertain their CF carrier status. The authors report that counselling had mostly allayed this when couples were interviewed six months after the initial test. However, since the screening was simply to determine (asymptomatic) carrier status, which is not essentially problematic in reproductive terms, this seems likely to have had an impact on expressed anxiety. Other researchers noticed no anxiety among a general population cohort screened for CF carrier status (Livingstone, 1994). A study of the psychological outcome of amniotic fluid in three risk groups (older mothers, mothers who had a previous child with DS, and mothers who had a previous child with NTD) found anxiety levels in relation to the test both differed between the groups and showed considerable variation within each (Everskiebooms, 1988). Different screening or testing programmes clearly have different implications for the participants, and there are no easy comparisons to be made or conclusions drawn. Although most literature in this area relates to genetic testing, some studies do focus directly on counselling. One report examined the impact of different counselling formats on mood. A psychological scale administered before and after counselling assessed mood change. The authors concluded that the use of different formats made no significant differences to mood, although there is no discussion of what the changes actually were (Fisher, 1981). Cull et al. carried out a similar assessment of differing counselling formats using the Spielberger state-trait anxiety inventory, and also found no significant differences between groups. Another study examined both clients’ expectations of counselling and its psychological impact, again using the Spielberger inventory (Michie, 1997). There was reduced adverse psychological impact when patient expectations were met in the counselling session. All these studies, however, are concerned with comparisons of counselling methods rather than counselling itself. The only study identified which explicitly focused on anxiety levels as a result of counselling concerned familial breast cancer (Lloyd, 1996). Counselees had higher breast cancer specific distress rates after counselling than before, despite being more informed. The potential for counselling to be a worrying or threatening experience is underlined. As Jarmas has pointed out, counselling may also have adverse psychological impacts on counsellors, an issue that does not yet seem to have attracted investigators. Nevertheless, anxiety reduction among those tested may be one of the less contentious outcome measures. 2. 4 Client satisfaction: The importance has also been defined in terms of clients’ satisfaction. In one study, 36 individuals who had received counselling for cancer were asked to rate their satisfaction both with the care provided by the clinical geneticist they had seen, and with general procedures at the clinic (L. P. ; Leschot N. J. , 1997). In another, clients were asked to rate counselling sessions in terms of clarity, depth of discussion and their willingness to raise issues; the ratings were examined for evidence of influence from the sex of the counsellor (Zare, 1984). However, both studies acknowledged the limitations of their approach, stressing the importance of relating such findings to qualitative analysis of the actual counselling sessions. Reported satisfaction is a questionable measure of process, since it does not necessarily relate to what actually occurred during the session. As Clarke et al. highlight, while research has focused on outcome, effectiveness is also fundamentally related to process. In their view, while outcome measures are valid in a research context, they are useless in practice, a position echoed by other commentators who argue that outcome measures used alone are both inappropriate and methodologically inadequate (Kessler, 1992). 3. Structural and Numerical Abnormalities There are two types of aberrations that karyotyping could be identified in the foetus – these are numerical and structural. Numerical aberrations depict loss or gain of chromosomes which might be one or more. The title aneuploidy has been given to such kinds of aberrations. The term trisomy expresses the occurrence of a single extra chromosome and the term polyploidy shows the occurrence of two or more chromosomes (Mosby, 2005). Structural chromosome rearrangements are considered to be the other main sort of aberration; this is an outcome of partition and reunification in a different configuration of chromosome. These aberrations also contain translocations, which includes the exchange of genetic materials among chromosomes. One of the most famous aberrations identified during the prenatal period are aneuploidies such as trisomy 21 (Down’s syndrome), trisomy 18 (Edward syndrome), trisomy 13 (Patau syndrome), and X and Y sex chromosome aneuploidies (Divane, 1994). 95% of live-born chromosomal aberrations occur as a result of them (Whiteman, 1991). Chronologically occurrences of various chromosome aberrations are very difficult in composition because certain aberrations have such negative side effect that the survival chances of the foetus are significantly reduced. Statistics and facts that are gathered on the occurrence of different aberrations on certain occasions must have to be present in relation to the number of births (which are before or after birth), occasionally in comparison to the numbers of amniotic samples examined, or at other times in terms of pregnancies. . Table1. Chromosome abnormalities commonly detected their frequency and consequences (Grimshaw, 2003). Chromosome number, shape, and size form the karyotype. In spite of the fact that every karyotype is varied for each organism, every cell in every organism has the same karyotype. Chromosomal abnormalities can be separated into two categories: numeric and structural (Figure 1) (Todd, 2000). Changes in chromosome numbers result in the addition (trisomy or triploidy) or loss (monosomy or aneuploidy) of a chromosome. Between and within chromosomes structural changes could appear. Regions between chromosomes can be traded (translocation) or donated from one to the other (insertion). In the same chromosome, regions can be lost (deletion), duplicated (amplification), or reversed (inversion). It is a challenge for medical professionals to correctly identify these structural alterations and following that counsel the patients (Todd, 2000). Figure:1 Diagrammatic representation of chromosomes and their structural alteration: A) Chromosomes 3 and 8 stained with giemsa (G-banding) at a resolution of the 400 band level. Each chromosome has a short (p) and long (q) arm that is separated by a centromere at one end and a telomere at the other. Chromosomes are described as metacentric (chromosome 3) or acrocentric (chromosome 8), depending on the position of the centromere. Bands and sub-bands are numbered from the centromere outward. B) Structural aberrations involving 2 chromosomes. Illustrated is a fragment from chromosomes 3 (yellow) and 8 (blue) undergoing translocation [t (3;8)(p21-pter;p21-pter)] and insertion [ins (3;8)(q21. 2-21. 3;q13. 3-22)]. C) Structural alterations involving a single chromosome illustrated (using chromosome 3) include amplification [dup(3)(p21-pter)], inversion [inv(3)(p21-pter)], and deletion [del(3)(p21-pter)] (Todd, 2000). Figure 2: The human karyotype and aberrations. A) The normal human karyotype consists of 46 chromosomes (23 pairs). Autosomes are chromosome pairs 1-22. The sex chromosomes consist of a pairing of the X and Y chromosomes (XX _ female; XY _ male). B) Each chromosome is composed of two chromatids. At the end of each chromatid is the telomere. The centromere (â€Å"clear zone†) is found in a centric or paracentric position. C) Numeric aberrations of the human karyotype appear in many diseases and syndromes. Most commonly, the change is an addition (trisomy) of loss (aneuploidy) of a chromosome. Down’s syndrome is an important example. D) Structural alterations are another important chromosomal aberration. Many types of structural alterations exist in human disease and syndromes. The Philadelphia chromosome, found in chronic myelogenous leukemia, is an important example and a major prognostic factor (Todd, 2000). 4. Methods Used in Genetic Counselling Programme 4. 1 Amniocentesis: Amniocentesis is one of several diagnostic tests that are carried out for mothers undergoing Genetic counselling. It detects the chromosome disorders that can occur in the unborn child. In this process, a sample of the fluid from the amnion is removed and then tested for disorders like Down’s syndrome, anaemia etc. This test is carried out during the 15th week of pregnancy. Amniotic fluid is used for different tests in the laboratory like karyotyping etc. However, amniocentesis increases the risk of miscarriage and therefore, this test is recommended only for women who have a high risk of chromosome abnormality. 4. 2 Conventional cytogenetics: For prenatal diagnosis the methods that are mainly used in genetic counselling are classified into two categories: Conventional Genetics and Molecular Cytogenetics (Bui, 2002). 4. 2. 1 Karyotyping In 1969 there was an expansion of karyotyping techniques for banding chromosomes, which allowed the detection of more subtle structural chromosome abnormalities. A karyotype is the exact organization (matching and alignment) of the chromosome complement of a cell. In a karyotype, chromosomes are arranged and numbered by size, from the largest to the smallest. Karyotype is the normal classification, which illustrates the normal or abnormal, constitutional or acquired chromosomal complement of an individual, tissue or cell line. To determine the numerical chromosomal abnormalities or structural rearrangements –mainly translocations- the conventional cytogenetic techniques should be used (Catalina, 2007). When full karyotype analysis is performed all the samples should be cultured enough so dividing cells are present. Then the cells are harvested, and the metaphase chromosomes are spread onto a microscope slide. The chromosomes are banded by enzyme digestion and then are analyzed by a cytogenetic expert. Advantages: Until now the gold standard for genetic tests is the conventional cytogenetic study, since it is the best one currently available for assessing the whole karyotype at one time. Moreover, it is inexpensive and detects abnormalities bigger than 3Mb in size (Catalina, 2007). Disadvantages: Only dividing cells can be assessed, there is a need for metaphase stage cells. No frozen tissue can be used. Moreover, it is a time-consuming method and due to the lack of automation in sample processing, the time needed to analyze and generate the final report is almost two weeks. Due to the difficulties of analyzing and interpreting the data, an experienced cytogenetic specialist is required (Catalina, 2007). 4. 2. 2 Molecular Cytogenetics Even though, Karyotyping remains the gold standard of chromosome analysis and still is the most frequently used genetic method in prenatal diagnosis, development of fluorescence in situ hybridization (FISH) technologies (Bui, 2002) is the most significant step in cytogenetics during the past 20 years. Moreover, over the past 30 years modifications in cytogenetic techniques have provided an opportunity to increase sensitive detection of chromosome abnormalities. The invention of FISH techniques has provided the most prominent advances in the fields of research and diagnosis. A complete dissection of complex chromosome rearrangements can be achieved by the new multicolour karyotyping techniques and also provides the prospect of identifying new recurring chromosome rearrangements. Comparatively interphase fluorescence in situ hybridization and genomic hybridization both hindered the use of metaphase chromosomes altogether and have allowed the genetic analysis of previously problematic and unidentifiable targets. New advances in comparative genomic hybridization to DNA microarrays help in achieving high resolution and automated screening for chromosomal imbalances. Rather than replacing conventional cytogenetics, these new techniques have extended the range of cytogenetic analyses when they are applied in a complementary fashion (Kearney, 2001). 4. 2. 2. 1 FISH Background: The most common practice that has been carried out in molecular cytogenetics is known as FISH. In 1988 it was first introduced in USA based clinical cytogenetics, and speedy progress has subsequently been witnessed in this field. In 1991 the first test was made in the UK. This method acquires chromosome-based probes accompanied by fluorescent labels which are attached to them; now these probes can be found in commercial kit form. Microscope systems are required for detection, which are available as basic fluorescence microscopes to advanced image analysis systems known as microscope and camera devices of cooled charged-coupled type. This test involves more effort and resources than presently practising FISH, which is a harder labour test than the existing karyotyping technique (Grimshaw, 2003). Prenatal diagnosis and FISH Test: Fluorescent In-Situ Hybridization studies have been conducted earlier on uncultured amniocytes with the acquisition of single chromosome-specific probes (for example for chromosome 21). However, these probes (centromeric repetitive or alphoid) showed vivid evidence of cross-hybridization between certain chromosomes (e. g. the two probes interacted for chromosomes 13 and 21). This finding paved the roads to the development of different types of probes (cosmid contig and YAC probes). It was successfully demonstrated that the usage of the cosmid prodes to identify Down’s syndrome (trisomy 21) in 1994, in a study of 500 uncultured amniotic fluid samples. After a couple of years, the UK introduced the use of YAC probes so to ensure speedy first reports on samples (Lowther, 1996). Although, evidence emerged which predicted that a mixture of five FISH probes could be utilised as a combined multicolour FISH hybridization experiment, when testing the five chromosomes most commonly linked with chromosomal abnormalities (21, 18, 13, X, Y). Further into that these 5-probe FISH test kits were manufactured and made available commercially (Grimshaw, 2003). Figure 3. Diagram of FISH procedures (Carpenter, 2001). A number of techniques, such as multicolour FISH (MFISH) and SKY FISH, have been developed from the FISH-based karyotyping of chromosomes. Fluorescent dyes used spectral karyotyping methods that jot together particular chromosomes regions. By utilizing a chain of specific probes each with changing quantity of dyes, unique spectral characteristics were found in different pairs of chromosomes (Catalina, 2007). There is a wide range of FISH techniques for both diagnostic and research applications. Since commercial availability of probes is increasing most clinical laboratories now use FISH as an addition to cytogenetic diagnosis. Metaphase FISH with specific gene probes provides an accurate assessment of rearrangements with a defined diagnostic or prognostic value, and interphase FISH provides the possibility of analysis on samples that would otherwise fail. One of the most significant advances has been in the development of multicolour FISH technologies which has culminated in FISH-based karyotyping methods. Metaphase CGH provides a global screening approach allowing the analysis of samples previously intractable to cytogenetic analysis. More recently, the development of CGH to DNA previously intractable to cytogenetic analysis. More recently, the development of CGH to DNA (Kearney, 2001). Advantages: FISH is a very rapid method, the results are ready within 24-48 hours. Also it is a sensitive and cost-effective and identifies both numerical and structural chromosomal abnormalities in interphase and metaphase nuclei, and permits rapid sex determination (Catalina, 2007). Limitations: However, FISH has some limitations such as cross-hybridization of non-specific fluorescence signals, non-specific background, and suboptimal signal strength. Though, small deletions, duplications and inversions cannot be identified by painting prodes (Catalina, 2007). 4. 2. 2. 2 Multicolour Whole-chromosome Painting (M-FISH AND SKY) The most prominent characteristic of FISH is its ability to simultaneously identify several targets by using variant colours (multicolour FISH). As early as 1989, as many as three targets could be visualized at the same time (Nederlof, 1989). By the early 1990s 7 ±12 different probes in different colours could be simultaneous detected (Dauwerse, 1992), (Ried, 1992). However, it was not until 1996 that developments in probe labelling and digital imaging systems allowed the visualization of the entire chromosome complement in 24 different colours (Schrock, 1996), (Speicher, 1996). The two techniques, M-FISH and SKY, both utilize DOP-PCR amplification of flow-sorted chromosomes and a ‘combinatorial’ labelling approach. The principle behind this for both M-FISH and SKY is the generation of more colours than there are fluorochromes available, by labelling with 1:1 mixtures of fluorochromes. The theoretical number of targets which can be discriminated in this way is 2n=1, where n represents the number of fluorochromes available. Using only five fluorochromes, this allows painting of the whole chromosome in twenty-four coloured complement (see Figure 5). Figure 5. M-FISH colour karyotype of a bone marrow metaphase from an AML patient. G-banding identified a balanced t(1;3)(p32;p13), and this was confirmed by M-FISH (arrows). However, M-FISH also identified a cryptic der(6)t(6;22) not visible by G-banding (arrow). Two copies of the der(6) are present in this cell (Kearney, 2001). The imaging system which is used to discriminate fluorochrome combinations is the only difference between SKY and M-FISH. M-FISH is acquiring different fluorochrome pictures for each of the five fluorochromes using specifically selected narrow band pass filter sets (Eils, 1998),(Speicher, 1996). SKY on the other hand uses a single exposure of the image and a grouping of cooled charge coupled device (CCD) imaging and Fourier transform spectrometry to analyze spectrum of the fluorochrome combinations (Schrock, 1996). Both of these methods use dedicated software to transfer the unique labelling combination for each chromosome into a pseudocolour. It is important to mention that both of them have already demonstrated hidden chromosome rearrangements in complex karyotypes such as in tumour cell lines and in haematological malignancies (Speicher, 1996), (Veldman, 1997). Disadvantages: As with other whole-chromosome painting methods, both M-FISH and SKY are not capable to detect small intrachromosomal rearrangements (inversions, deletions, duplications). Both techniques can not detect mosaic cells. In particular, the limit of resolution for telomeric rearrangements is 2 ±2. 5 Mb (Brown,2000), (Uhrig,1999). Additionally, to overcome these limitations complementary FISH approaches are required. In addition to this, latest reports state that although M-FISH and SKY have proved to be extremely useful in prenatal, postnatal, and cancer cytogenetics, these technologies have innate limitations that, in certain cases, could result in chromosomal misclassification. Most multicolour karyotyping errors have a similar mechanistic origin. Structural rearrangements, which compare non-homologous chromosome material, often come up in overlapping fluorescence at the interface of the translocated segments; called occasionally as â€Å"flaring† (Lu, 2000). This effect can obscure or alter the fluorescence pattern of adjacent chromatin, which could lead to misinterpretation (Lee, 2001). 4. 2. 2. 3 Comparative genomic hybridization (CGH) CGH is a technique that presents an overview of the whole genome and allows the detection of DNA copy number changes. It is a powerful option instead of chromosome banding and FISH. This method can detect a genome screening of chromosomal differencies without previous information about genomic regions which could be a potential target. CGH is a substitute method which reveals unbalanced chromosomal changes that may happen in hESCs lines during lengthy-span cultures, especially in cases where it seems difficult to obtain high quality metaphases (Catalina, 2007). Advantages and Limitations of CGH: The obvious edge of the CGH technique is that it requires only the genomic DNA; moreover, CGH does not require prior knowledge of the genomic region of interest. CGH can also identify copy number changes, increases and losses of regions of chromosome. Though, CGH is able to identify a number of quantitative genetic alterations including duplication or deletion of single chromosome bands. The CGH analysis also indicates the presence of genetic abnormalities that are not detected by other cytogenetic or molecular approaches. The turgidity of this technique in detecting low copy number gains or losses is in between 10-20Mb, therefore the detection limit of amplification is 2Mb. However, CGH has several limitations such as inability to detect chromosomal balanced translocation, inversions, and intragenic rearrangements (Catalina, 2007). Figure 7: Comparison of cytogenetic techniques for identifying chromosomal abnormalities (Speicher, 2005) Although the advances of the techniques utilized in genetic counselling are major, all of them come with their own share of advantages and disadvantages. The same is summarized in Table 2. Quantitative fluorescent polymerase chain reaction (QF-PCR) QF-PCR combines the benefits of relative and competitive RT-PCR. It is accurate, specific, high throughput and relatively easy to execute. Real time PCR automates the lengthy relative RT-PCR process by quantitating reaction products for each sample in every cycle. RT-PCR systems detect and quantify the fluorescent reporter. The signal of this reporter increases in direct proportion to the amount of PCR product in the reaction. The reporter is a double-strand DNA which is bound to a specific dye (SYBR Green) and upon excitation emits light. If the dye is included in PCR reaction as PCR product accumulates the fluorescence increase. An alternative technique for quantifying PCR products is TaqMan, which depends on fluorescent resonance energy transfer (FRET) of hybridization probes for quantitation. The probe hybridizes to an internal region of a PCR product. After irradiation the excited reporter dye transfers energy to the nearby quenching dye, which results in a non-fluorescent substrate. The advantages of this method are that it is inexpensive, simple to use, and sensitive The future of prenatal diagnosis: Full karyotype or molecular cytogenetics tests? The introduction of rapid molecular testing of all prenatal samples has brought up the question of the need for full karyotype analysis of all samples. When ultrasonography shows chromosomal abnormality, and there is no aneuploidy can be identified by frequent testing, full karyotyping is definitely required. However, when women have been identified by serum screening and/or maternal age as being at increased risk of Down’s syndrome they undergo persistent testing. â€Å"Double testing† of these women in a public-funded health service could be considered as unjustifiable and there are also down points for the parents. The time between the results of the rapid test and the full karyotyping could cause needless anxiety. Additionally most parents do not realize the significance of the full karyotyping; because they only worry about Down’s syndrome and not for the possibility of other abnormalities. Full karyotype analysis could identify abnormalities of unidentified importance, likewise the presence of very small â€Å"marker† chromosomes, clearly balanced chromosome rearrangements, or regions of variability, which could be hereditary. These outcomes could frequently create counselling difficulties, and cause problems for the parents in how to deduce and choose between anxiety and pregnancy termination during an ongoing pregnancy. When a chromosome rearrangement is found in one of the parents, full karyotyping is needed to test for abnormalities arising as a result of the rearrangement. However, recent advances in the policy of pre-implantation genetic diagnosis for rearrangement carriers (Scrivn, 1998) have permited rapid prenatal testing for chromosome imbalance using sub telomere probes (Pettenati, 2002). The UK National Screening Committee (UKNSC) suggested in 2004 that there is no need for karyotyping when screening for Down’s syndrome and instead prenatal diagnosis with FISH (fluorescence in-situ hybridisation) or PCR as rapid diagnostic tests as should be offered. Furthermore, UKNSC also suggested that the two previous tests should only be included for trisomies 13, 18, and 21. Before introducing the radical step of rapid testing alone for pregnancies at risk of Down’s syndrome, it is important to set up the significance and predicted effect of such a change in policy. Full karyotype results of prenatal samples from these referral categories can be audited to determine how many clinically significant chromosome abnormalities are likely to be undetected if rapid testing alone had been carried out. Recent studies which are investigativing karyotype abnormalities in prenatal samples referred for raised maternal age (RMA) or increased Down’s syndrome risk identified by serum screening will be reviewed in the following paragraph: In 1,130 prenatal samples, which were all referred for RMA or elevated risk of Down’s syndrome, an important clinical abnormality in chromosome 8 was identified (deletion of the short arm), which would not be identified by rapid testing (Thein et al). This is responsible for 0. 08% of the sample group. Thilaganathan et al. reported 3,203 amniotic fluid samples, were referred for a number of reasons. Rapid testing here did not detect all clinically significant abnormalities, which were detected with ultrasound. On another study, Ryall et al.reported 2,737 prenatal samples from pregnancies referred as serum screen +ve and an abnormality in chromosome 2 and 6 were detected. In the largest cohort study with 20,923 referrals around 30 important abnormalities were identified which includes four small marker chromosomes (Lewin et al. ). Among them, three pregnancies had trisomy 8, three trisomy 9, and three trisomy 16; and were all non-mosaic and therefore non-viable. Additionally thirteen cases of structurally abnormal chromosomes were identified, and complex abnormalities were found in four pregnancies. Rapid testing would detected as far as 99. 2% of clinical significant abnormalities, when pregnencies are reffered to RMA or serum +ve. In these studies, 196 balanced rearrangements or other good prognosis anomalies were found, which would have required parental karyotyping. This would lead to anxiety and in some cases termination of pregnancy. 5. Summary The future seems very exciting since the new developments in genetic information will present great challenges for genetic counselling. Medical doctors are currently facing problems in understanding and retaining genetic information outside their own scientific area. In some cases it is still not clear when test should be offered, since if a family is affected legal action could be used to question why an available test was not offered. Eventually, more diagnostic techniques would help to identify and treat more effectively, but not without false positives. Though, queries about which disorders to diagnose and when, (e. g. premarital, pre-conceptional, foetal, childhood, adulthood) will continue. It is important to mention that molecular cytogenetic increase the progress of prenatal diagnosis used in genetic counselling programmes to reveal chromosomal abnormality. The molecular cytogenetic techniques provide speed, accurate, ease and reliable diagnosis although there are some limitations associated with these techniques. However, if combination of the conventional techniques and molecular ones wil

A View on Letter from Birmingham Jail essays

A View on Letter from Birmingham Jail essays A View on Letter from Birmingham Jail Being a letter (correspondence), this article, does not have a title per say, it has come to be known as Letter from Birmingham Jail. In the letter the writer, Dr. Martin Luther King Jr. (Dr. King) discusses his views on what was happening in the Civil Rights Movement and why. Dr. King is a credible writer and becomes qualified to write on this topic since he is possibly the best-known leader for the movement for African-American civil rights. Being a leader in this movement Dr. King adds more strength to his letter by being very appealing to authority, establishing credibility, character, and confidence; he gains all this by telling the reader about his position in the Civil Rights Movement. Dr. King has a certain type of philosophy that most people tend to agree with. Dr. King wrote this letter while he was in the Birmingham jail where he was detained after being arrested by the Birmingham police for his part in a demonstration. He was in Birmingham because an affiliate invited to Birmingham to participate in a non-violent direct action program. Dr. King sent this letter to Fellow Clergymen and has since been published in many forms because of the historical impact it holds. Initially directed towards the eight clergymen that had made statements that his present activities were unwise and untimely; Dr. King wrote this letter because he felt the need to defend his actions. This letter is easy for the reader to understand and very clear about the purpose, because of the good use of ethos, pathos, and logos. It appears he was trying to get the readers attention to let them know that he was going to explain his ideas and actions. He is very effective in his use of ethos and logos when explaining his purpose and reasoning for the actions. First, LOGOS is an effective appeal that Dr. King uses in this letter by being logical ...

The Totality of the Operations in All Aspect of the Business Research Paper

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Legal Aspects of Business Decisions Essay Example | Topics and Well Written Essays - 250 words

Legal Aspects of Business Decisions - Essay Example This analysis forces courts to consider the pro-competitive effects of the restraint as well as its anticompetitive effects. Certain categories of restraints to be illegal per se: that is, they are conclusively presumed to be unreasonable and therefore illegal. For those types of restraints, the court does not have to go any further in its analysis than to recognize the type of restraint, and the plaintiff does not have to show anything other than that the restraint occurred. Three elements must be alleged to sustain a cause of action under section 1 of the Sherman Act, 15 U.S.C. 1 (1982): a contract, combination or conspiracy; a restraint of trade; and an effect on interstate commerce. Weiss v. York Hospital, 745 F.2d 786, 812 (3d Cir.1984), cert. denied, 470 U.S. 1060, 105 S.Ct. 1777, 84 L.Ed.2d 836 (1985). Restraints of trade can be classified as horizontal or vertical. A horizontal agreement is one involving direct competitors at the same level in a particular industry, and a vertical agreement involves participants who are not direct competitors because they are at different levels. Thus, a horizontal agreement can be among manufacturers or retailers or wholesalers, but it does not involve participants from across the different groups.

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Bookertee - Essay Example He stressed that Blacks were not ready for the traditional form of education; rather they should take up an occupation or a skill by which they can support themselves. Washington showed a path to the struggling Negroes by which they can create their basic identity and be self sufficient in the long run. However, there were negative aspects to this plan as future academics such as Du Bois pointed out. Washington had stressed that the Blacks needed selective education, that they were not ready to be educated in the traditional form. But, according to Du Bois the African Americans deserved the same form of education as the Whites. He believed in the philosophy that Fast and Fury wins the race. According to him unless and until the Blacks made a struggle to educate themselves they would limit themselves to the lower segment of society prone to be harassed by the Southern Whites. Another negative aspect of the plan was Washington’s stress that the Blacks adopt a subordinate role towards the Southern Whites. He is actually asking the Blacks to let go of their struggle against Whites and continue to be backward and underprivileged member of the society. IF the Blacks had continued to follow his advice, there would not have been many prominent African Americans in the country. According to me Washington was right in asking the Blacks to take an academic route to liberate them from White oppressiveness. He asked the members of his community to stick to education and acquire any useful trade so as to gain economic independence. A steady income would help in supplementing all the essential elements of life. Education would open their mind to newer possibilities in life and make them come out of their shell. This policy is still followed by a number of African American of today who have shifted to trade and commerce to acquire richness in life and move ahead in the economic ladder. a. A Negro Love Story: This poem

Hacking; dangerous effects on the society

Hacking; dangerous effects on the society Abstract Hacking is just like a cancer that has very dangerous effects on the society. Today in this modern world, where measures have been taken to improve the security level in the distributed systems hackers have found a way to crack into systems and take away information. In this paper, I will explain you few aspects of hacking that has caused of its existence and few techniques through which we can minimise this. What are the different issues and motivations that arise in a person that he opts for hacking? Is money, thrill or something to break the rules inspires the hacker to indulge into such acts are discussed in this paper. This paper also gives you an insight to consider how important the network security plays to avoid hackers to steal away information that is very confidential. Measures are to be taken in order to remove these possibilities. In recent years we have seen a drastic change in the field of IT, where electronic commerce, email, online shopping, online banking, information bank of numerous data, software development has improved leaps and bounds. As the technology has increased to new heights the hackers have found a way to get easy money. They find ways to get into government confidential files, personal banking details, steal away their money from the banks, implant a Trojan or virus into different computers to make them vulnerable to work. In this paper I have thrown some light on hackers skills, their perspective, their targets. Introduction Hacking according to oxford dictionary means to gain unauthorized access (to data in a computer). Banks defines hacking as something that boring mainframe computer operators did to improve performance and battle boredom. [1]. Here a bank focuses on boredom as the reason of hacking. Darlington believes hacking is not limited to accessing data or information but also includes an attack on the privacy of all people [5]. Almost all different opinions agree on the illegality of hacking. On the other hand the word hacker is the agent of hack or hacking and it was defined as a person who enjoys accessing files whether for fun, imposing power or the interest related to the accessed files or data according to Taylor [8]. While Marotta has a negative view of the hacker as a data lord, a barbarian who takes what he wants [9]. Himanen defines hacker as any person who performs illegal actions whether they were related to computer or not which means the usage of a device apart from its functionality. Seems hacking according to Himanen is related to any illegal or unauthorized action [7]. Clear from the definitions mentioned above that there is a controversy that encounters the judgment and definition of hacking, controversy aroused because its hard to decide exactly what the aim is behind hacking or how to know the mentality of the hacker. Thats why the ethics and motivation of hackers should be paid attention and discussed then understanding the hacker will be much easier. Who is the hacker? According to Taylor, Hacker can be anyone who has knowledge of things; he can be a graduate or a computer professional working at a multinational company. He can be one amongst us. A is part of the society, a computer professional who wants to use technology for his own benefit [11]. Hackers are experts and professional people who first enjoy the technology and through research and development they gain more interest and you never know when this curiosity of technology changes into crime. People must realise that the technology is good lest it is used for the countries benefit, but it has adverse affect when things turn upside down, that the hackers learn this technique in order to gain profits for themselves through illegal ways. Levy described hackers in regard to the history; she divided the life history of hackers into three generations: the first generation of hacking was made of experts of computer programming who never stopped improving their skills then misuse them, the secon d generation was made of computer hardware developers who found hacking and accessing data and information for free as an appealing idea while the third generation included developers of games architecture [8]. And I think the fourth generation of developers are those who know about computers and have just enough knowledge about computer programming. Pipkin classification of hackers depends on the functionality, in other words the classification depends on the way hacker interacts with what is being hacked. Hackers were classified into three different types; the first type is called In-house hacker. An in-house hackers actually works inside the company, who knows the system security, has access to all the features. His motivation to hacking might be because he wasnt recognised as a potential candidate for promotion or because he was betrayed by his fellow colleagues. The second type of hackers is a super hacker who doesnt interact with the system, but remotely monitors all the movements or the data transactions that are going on and depending on the situation and the amount of money that is being transferred he then changes that transaction into his account. And finally, comes the professional hacker, he is very strong and capable of getting any type of data from anywhere, he has the ability to manipulate things and change them t o his benefit, programming Trojans and software that get installed on the system through hidden window and then sits on the system[10]. Motivations behind Hacking: Hackers psychology and the fuel that encourages him/her to perform such illegal activities, also because hackers view about what they are doing is far different from our views as victims Furnell ([6] Pipkin, in his paper Halting the hacker, says the challenging part of the hackers personality as the biggest motivation; this means that the hacker feels the joy and excitement when hacking systems that are provided with the almost perfect security tools [10]. One of the main reasons for hacking is excitement where hackers find adrenalin rush to break the law, to find an easy access to earn money by hacking crucial information of the customers by creating unreal shopping websites and obtaining payment details, credit card details. Furnell judged hackers depending on the harm they cause whatever was their motivation, because hacking is a disease and should be removed so that the effect of hacker attacks will be minimized [6]. The motivations behind hacking are an issue that is discussed heavily due to the importance of understanding the An ethical hacker attempts to duplicate the intent and actions of malicious hackers without causing harm. Ethical hackers conduct penetration tests to determine what an attacker can find out about an information system, whether a hacker can gain and maintain access to the system, and whether the hackers tracks can be successfully covered without being detected. The ethical hacker operates with the permission and knowledge of the organization they are trying to defend and tries to find weaknesses in the information system that can be exploited. In some cases, to test the effectiveness of their information system security team, an organization will not inform their team of the ethical hackers activities. This situation is referred to as operating in a double blind environment. To operate effectively, the ethical hacker must be informed of the assets that should be protected, potential threat sources, and the extent to which the organization will support the ethical hackers efforts. Hacker and Ethical Hacker Characteristics and Operation: Hackers can be categorized into the three general classes of black hats, gray hats, and white hats. A black hat hacker or cracker has the necessary computing expertise to carry out harmful attacks on information systems. A gray hat is a hacker with a split personality. At times, this individual will not break the law and, in fact, might help to defend a network. At other times, the gray hat hacker reverts to black hat activities. The white hat individual usually has exceptional computer skills and uses his or her abilities to increase the security posture of information systems and defend them from malicious attacks. This individual might be an information security consultant or security analyst. Entities that perform ethical hacking functions for organizations usually fall into one of three categories: white hats, former black hats, and independent consulting organizations. The white hat ethical hacker has the appropriate computer skills and understanding of the black hat hacker mentality and methods. This person might be an independent consultant hired to perform ethical hacking activities. The former black hat hacker is, we might hope, reformed and brings actual black hat experience to his or her work. There is a concern about this individual in that you can never be certain that he or she will not revert to their former malicious activities. The third category of ethical hacker is taken by consulting companies that perform a variety of services for organizations including accounting, auditing, and information system security. Related Types of Computer Crime and attack: Different kind of hacking attacks are considered as computer crimes. The following is the list of crimes which are committed frequently: Password Hacking. Hackers find a way to illegally hack into the passwords of users of federal bureau, banks in order to gain benefits from them. Network intrusions. Malicious Trojan, worms and viruses to gain access into the information systems. Cheat. Illegal use of people identities such as credit card details. Software piracy. Illegal copying and use of software Viruses. Viruses, Trojan horses and worm cause the computers to become more vulnerable and susceptible to hardware damage. IP address spoofing. Disguising the IP address and using that to gain illegal access into countries most confidential files. Money Laundering Illegally acquiring funds through the manipulation and falsification of financial statements and illegal transactions. Data-modification. The modifying all the data. Smuggling of files. Gain illegal access of confidential files including bodies like military/government networks, communication systems, power grids, and the financial community Pipkin lists a number of hacking attacks that are most commonly used in breaking system and causing disruption and damage for services. These attacks can be summarized as following [10]: Software piracy is a criminal offense. Many hackers have indulged in making copies of software and selling them to gain profits on their own. The companies who develop these software will have to bare all the losses only because of someone who is illegally misusing software. Stealing confidential files through illegal access of the companies most confidential files. Hackers have many such motives, few of them like denial of services to the user and to make hardware conflict, making unwanted popup, causing trouble, terrorism. Taylor listed the main characteristics of hacking attacks in three points [8]: Simplicity: means that the attack should be simple in appearance but the effects are impressive and the results will be as pleasing to the hacker as what he planned for. It means that do your job in a smart and easy way. Mastery: the methods used in hacking contain sophisticated knowledge which is difficult for anyone to understand. The reason behind mastery is to make sure that the hacker is the only one who can solve the problem being caused. Illicitness: means that the act is against all rules and laws. Conclusion: Earlier hackers were considered to be genius because they helped in many ways in the development of computers and internet technology as such, but in this modern world where personal benefit has played a major importance in ones life, people are often attracted to things they can do and gain through illegal entry into people privacy and using for their own benefits. Different motivations and opinions have been discussed in this paper, but if we consider them as a person they are a live example of genius because of their abilities of doing the unbelievable and unachievable by getting more involved into the programming and understanding the loop holes in the security systems. I think because of these, scientists and researchers have spent lots of technology to improve the systems security and make them more secure so that no illegal access can be gained. In my own view understanding the different perspective of a hacker, we can develop a much more secure and much more sophisticated environment and provide a safer world for transactions and online shopping. The bad things of them should be taken into good only to benefit our country and its progress. Bibilography: Banks, Michael A. (1997), Web psychos, stalkers, and pranksters: How to protect yourself online. Arizona (USA). Chakrabati, Anirban and Manimaran, G. (2002), Internet infrastructure security: A Taxonomy, IEEE Network, November/December 2002, P.13. CNET (2001), FBI hack raises global security concerns Crucial paradigm (2003), Hacking attacks-How and Why. Darlington, R (2001), Crime on the net Furnell, Steven. (2002), Cybercrime: Vandalizing the information society, Boston; London: Addison-Wesley. Himanen, Pekka. (2001), The hacker ethic and the spirit of information age, Great Britain. Levy, Hacker: Heroes of the computer revolution, Hackers: Crime in the digital sublime. Hackers: Crime in the digital sublime Halting the hacker: A practical guide to computer security Taylor, Paul A. (1999), Hackers: Crime in the digital sublime, London.